The Basic Study on ic - X Imaging by # { 246 } - Curvefor the Detection of a Monoclonal B - Cell Population in the Peripheral Blood

Recently. ic-X analysis with the “D” value was developed by Ault to detect a minor population of malignant B cells in peripheral blood. This analysis is based on the KolmogorovSmirnov test, and the D value is calculated by a flowcytometer and a computer. We have recently devised a more sensitive parameter for the sc-X analysis than the D value called the .-curve (&c); the #{244}c applies the same principle as that of the D value. Mixing experiments with k-type and A-type chronic lymphocytic leukemia cells revealed that the k could not only detect a minor population of malignant sc-B cells, but also that of malignant X-B cells using more sensitivity than the D value. A total of 49 blood